Investigating sex-specific associations of lipid traits with type 2 diabetes, glycemic traits and sex hormones using Mendelian randomization
Authors' conclusion
Lipid traits potentially relevant to CVD aetiology do not exhibit contrasting associations with CVD and type 2 diabetes. However, higher TG is associated with higher type 2 diabetes risk and glycemic traits, which in turn further increases TG specifically in women, possibly driven by sex hormones.
Study context
- Population
- People of European ancestry in the largest relevant sex-specific genome-wide association studies (GWAS)
- Comparison
- Genetically predicted apolipoprotein B (apoB), triglycerides (TG) and Lp(a) vs T2D, glycemic traits and sex hormones, by sex
- Outcome
- Sex-specific associations of apoB, TG and Lp(a) with T2D and glycemic traits
Methodological detailssex-specific, two-sample summary GWAS data, European ancestry, replication where possible
- Sex-specific
- Two-sample summary GWAS data, European ancestry
- Replication where possible
Main finding
As reported in the abstract
Higher TG and higher T2D risk in women, OR per SD
1.44
95% CI 1.26 to 1.65
Further findings
TG and sex hormones
- Higher TG associated with lower testosterone in women and higher testosterone in men
- Higher TG associated with lower estradiol in men and women
Genetic liability to T2D and lipid traits
- Liability to T2D associated with higher TG in women
- Liability to T2D possibly associated with lower apoB in men
Original publication
Investigating sex-specific associations of lipid traits with type 2 diabetes, glycemic traits and sex hormones using Mendelian randomization. Cardiovasc Diabetol. Published 9 January 2023. doi:10.
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