Gestational diabetes & diabetes in pregnancy
DNA methylation risk score for type 2 diabetes is associated with gestational diabetes
Authors' conclusion
For the first time, we show that DNA methylation marks for T2DM are also associated with GDM, suggesting shared epigenetic mechanisms between GDM and T2DM.
Study context
- Population
- Pregnant women in two pregnancy cohorts; DNA methylation in peripheral blood leukocytes measured at gestational age 28 ± 2two cohorts
- Participants
- 480 vs 32
- Exposure
- DNA methylation risk score for T2D and gestational diabetes mellitus (GDM)
- EPIPREGn = 480
- EPIDGn = 32
- Outcome
- Association of an MRS for T2D (based on CpG hits from a published epigenome-wide association study (EWAS) of T2D) with GDM
Methodological detailstwo independent pregnancy cohorts, mixed models logistic regression
- Two independent pregnancy cohorts
- Mixed models logistic regression
Main finding
As reported in the abstract
GDM per MRS for T2D
MRS for T2DOdds ratio (95% CI)P value
Unadjusted model
1.3(1.1–1.8)
P = 0.002Adjusted for age, pre-pregnant BMI, family history of diabetes and smoking status
1.4(1.1–1.7)
P = 0.00014Per MRS for T2D, as printed
Observational data: associations, not effects.
Further findings
Individual CpGs associated with GDM (meta-analysis)
- CpGs associated with GDM (cg14020176, cg22650271, cg14870271, cg27243685, cg06378491, cg25130381)
- 6
- Some of their mQTLs were related to T2D and GDM
Original publication
DNA methylation risk score for type 2 diabetes is associated with gestational diabetes. Cardiovasc Diabetol. Published 13 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →