Gestational diabetes & diabetes in pregnancy
Association of prenatal glycemic marker cumulative exposure with placental DNA methylation change
Authors' conclusion
Increased glycemic marker exposure was associated with placental DNA methylation near genes enriched for inflammatory and cardiometabolic pathways. Placenta-mediated epigenetic mechanisms may link maternal glycemic dysregulation and offspring disease risk.
Study context
- Population
- Pregnant women with glycemic markers measured at 8–13, 16–22, 24–29 and 34–37 gestational weeks; placental DNA methylation by Illumina array
- Outcome
- Association of cumulative glycemic exposure (AUCgluc, AUCinsl, AUCHbA1c) with placental DNA methylation
Methodological detailsstratified by fetal sex
- Stratified by fetal sex
Main finding
As reported in the abstract
Placental DNA methylation associated with glycemic marker AUC
- Sex-specific methylation associations identified at FDR-adjusted P < .05
- 4
Further findings
Correlation of differentially methylated sites with neonatal anthropometry and placental weight
- Higher methylation at cg15608939 in males correlated with increased birth weight
- Lower methylation at cg05471842 in females correlated with increased birth weight
- Lower methylation at cg23951198 in males correlated with increased placental weight
Pathway enrichment of genes mapped to top CpGs
- Enriched for metabolic, immune and inflammatory pathways; linked to cardiometabolic diseases and traits
Original publication
Association of prenatal glycemic marker cumulative exposure with placental DNA methylation change. J Clin Endocrinol Metab. Published 8 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →