Differential weight‐loss responses of APOA2 genotype carriers to low‐carbohydrate and low‐fat diets: the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) trial
Authors' conclusion
This study highlights the importance of evaluating genotype-diet interactions in weight-loss trials to better inform precision nutrition interventions.
Study context
- Population
- Adults aged 18 to 50 years with BMI 28 to 40 kg/m² in the 12-month DIETFITS trial; APOA2 rs5082 genotypes TT vs C allele carriers (CT + CC) who met the SAT intake criterion at all three time points
- Participants
- 609 adults
- Comparison
- Healthy low-carbohydrate (HLC) vs healthy low-fat (HLF) diet, by APOA2 rs5082 genotype (TT vs C allele carriers)
- Primary endpoint
- Weight loss
- Follow-up
- 3, 6 and 12 months
Primary result
As reported in the abstract
Weight loss, HLC vs HLF, by APOA2 genotype
- TT genotype: significantly more weight lost on HLC than HLF at 3, 6 and 12 months
- C allele carriers: more weight lost on HLC only at 3 months, not at 6 or 12 months
Further findings
APOA2 genotype-by-SAT intake interaction on weight loss · 12 months
- Interaction observed only at 12 months
Weight loss in participants not consistently meeting the SAT intake criterion
- No significant weight-loss differences among APOA2 genotypes
Original publication
Differential weight‐loss responses of APOA2 genotype carriers to low‐carbohydrate and low‐fat diets: the DIETFITS trial. Obesity (Silver Spring). Published 1 May 2025. doi:10.
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