Association of serum 25‐hydroxyvitamin D with sarcopenic obesity risk: a longitudinal observational study from the UK Biobank
Authors' conclusion
Higher serum 25(OH)D concentration was significantly associated with a lower risk of SO incidence in a dose-response relationship.
Study context
- Population
- UK Biobank cohort participants, analysed by sex1,086 incident sarcopenic obesity (SO) cases
- Participants
- 46,535 participants
- Exposure
- Serum 25D concentration quartiles
- Outcome
- Incident sarcopenic obesity (SO)
- Follow-up
- Median 8.74 (IQR 6.70-11.06) years
Methodological detailslongitudinal observational, UK Biobank, multivariable-adjusted Cox proportional hazards models, restricted cubic spline analysis, sex-stratified
- Longitudinal observational
- UK Biobank
- Multivariable-adjusted Cox proportional hazards models
- Restricted cubic spline analysis
- Sex-stratified
Main finding
As reported in the abstract
Incident SO · median follow-up 8.74 years
Hazard ratio (95% CI)P value
Q2vs Q1female individuals; multivariable-adjusted
0.66(0.53–0.82)
P < 0.001for trendQ3vs Q1female individuals; multivariable-adjusted
0.53(0.41–0.67)
P < 0.001for trendQ4vs Q1female individuals; multivariable-adjusted
0.43(0.33–0.55)
P < 0.001for trendQ2vs Q1male individuals; multivariable-adjusted
0.86(0.66–1.10)
P < 0.001for trendQ3vs Q1male individuals; multivariable-adjusted
0.68(0.56–0.92)
P < 0.001for trendQ4vs Q1male individuals; multivariable-adjusted
0.40(0.29–0.54)
P < 0.001for trendObservational data: associations, not effects.
Further findings
Nonlinear association of 25(OH)D with SO risk (restricted cubic spline)
- Female individuals: nonlinear association
- pnonlinear = 0.043
- Male individuals: nonlinear association
- pnonlinear = 0.008
Original publication
Association of serum 25‐hydroxyvitamin D with sarcopenic obesity risk: a longitudinal observational study from the UK Biobank. Obesity (Silver Spring). Published 1 May 2025. doi:10.
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