Diabetic complications in women with type 2 diabetes and polycystic ovary syndrome
Main finding · Diabetic complicationsResult — go to the resultAdjusted hazard ratio 0.70 95% CI 0.60–0.82Authors' conclusion
The findings of the present register study suggest that PCOS does not seem to increase the risk of diabetic complications. However, studies with longer follow-up and clinical data, such as body mass index, are needed to verify this.
Study context
- Population
- Women with T2D in the nationwide Diabetes in Finland database, 1996–2017
- Participants
- 1,288 vs 177,555
- Exposure
- Polycystic ovary syndrome (PCOS) + T2D vs T2D without PCOS
- PCOSn = 1,288
- Controlsn = 177,555reference
- Outcome
- Diabetic complications: composite of retinopathy, neuropathy, nephropathy, cardiovascular, cerebrovascular or foot complications, and all-cause death
- Follow-up
- 1996-2017
Methodological detailsCox regression with PCOS as time-dependent variable, matched sub-analysis
- Cox regression with PCOS as time-dependent variable
- Matched sub-analysis
Main finding
Diabetic complications
Adjusted hazard ratio
0.70
95% CI 0.60–0.82
PCOSvs Controls
aHR 0.70 (95% CI 0.60–0.82)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Age at T2D diagnosis
| Outcome | PCOS | Controls |
|---|---|---|
| 20-year cumulative incidence of diabetic complication after T2D diagnosis (unadjusted) · matched sub-analysis | 35% | — not stated in the abstract |
— not stated in the abstract
- 20-year cumulative incidence of diabetic complication after T2D diagnosis (unadjusted): Matched controls 48%
Age at T2D diagnosis
- Significantly lower with PCOS
Original publication
Diabetic complications in women with type 2 diabetes and polycystic ovary syndrome. Eur J Endocrinol. Published 21 February 2025. doi:10.
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