Intensive glycemic control in adults aged 80 years and older: A randomized trial evaluating diabetes complications and competing mortality
Authors' conclusion
In adults aged 80 years or older with type 2 diabetes, intensive glycaemic control improved glycaemic levels but did not reduce vascular events and increased the risk of severe hypoglycaemia.
Study context
- Population
- Independently ambulatory adults aged ≥ 80 years with T2Drandomized 1:1
- Participants
- 206 adults
- Comparison
- Intensive glycemic target vs conservative target
- Intensiven = 102
- Conservativen = 104reference
- Primary endpoint
- Composite:
- Microvascular
- Macrovascular events
- Follow-up
- 5 years
Methodological detailsprospective, open-label, single-centre
- Prospective
- Open-label
- Single-centre
Primary result
As reported in the abstract
Intensive vs ConservativeHazard ratio (95 % CI)
Microvascular events
1.24(0.76–2.04)
Macrovascular events
1.02(0.36–2.92)
Further findings
Mean HbA1c · 5 years
P = 0.005
Competing mortality
- Cumulative incidence of death exceeded that of vascular events
Safety
Events
| Outcome | Intensive | Conservative |
|---|---|---|
| Severe hypoglycemia requiring hospitalization | 7 | 1 |
Original publication
Intensive glycemic control in adults aged 80 years and older: A randomized trial evaluating diabetes complications and competing mortality. Diabetes Res Clin Pract. Published 3 August 2026. doi:10.
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