Intensive Blood-Pressure Control in Patients with Type 2 Diabetes
Primary resultResult — go to the resultHazard ratio 0.79 95% CI 0.69–0.90Authors' conclusion
Among patients with type 2 diabetes, the incidence of major cardiovascular events was significantly lower with intensive treatment targeting a systolic blood pressure of less than 120 mm Hg than with standard treatment targeting a systolic blood pressure of less than 140 mm Hg.
Study context
- Population
- Patients aged ≥50 years with T2DM, elevated SBP and increased CVD risk, 145 sites in China
- Participants
- 12,821 patients
- Comparison
- Intensive SBP target <120 mm Hg vs standard target <140 mm Hg
- Intensive treatmentn = 6,414
- Standard treatmentn = 6,407reference
- Primary endpoint
- Composite of:
- Nonfatal stroke
- Nonfatal MI
- Treatment or hospitalization for HF
- CV death
- Follow-up
- Median 4.2 years
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Hazard ratio
0.79
95% CI 0.69–0.90
P < 0.001
Events by treatment group
Intensive treatment
1.65 events per 100 person-years
393 of 6414
Standard treatment
2.09 events per 100 person-years
492 of 6407
Intensive treatmentvs Standard treatment
HR 0.79 (95% CI 0.69–0.90); P < 0.001
Further findings
SBP · 1 year
Median Intensive treatment 118.3 mm Hg · Standard treatment 135.0 mm Hg
Safety
Serious adverse events
- Similar in the two groups
Symptomatic hypotension and hyperkalemia
- More frequent with intensive than standard treatment
Original publication
Intensive Blood-Pressure Control in Patients with Type 2 Diabetes. N Engl J Med. Published 16 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →