Trends in Peripheral Artery Disease, Lower-Extremity Revascularization, and Lower-Extremity Amputation in Incident Type 2 Diabetes: A Danish Population-Based Cohort Study
Authors' conclusion
In recent decades, the cumulative incidence of LE complications substantially decreased in patients with incident type 2 diabetes while remaining stable in the general population.
Study context
- Population
- Patients in Denmark diagnosed with T2D in 1996–2015, followed until 2020; 53% male, median age 62 years
- Participants
- 349,454 vs 1,025,054
- Exposure
- Incident T2D diagnosed 2011-2015 vs 1996-2000; T2D vs matched general population
- Type 2 diabetesn = 349,454
- General populationn = 1,025,054reference
- Outcome
- 5-year cumulative incidences of first-time PAD, LE revascularization and LE amputation
- Follow-up
- 5 years
Methodological detailsage and sex matched with as many as three general population individuals
- Age and sex matched with as many as three general population individuals
Main finding
As reported in the abstract
5-year cumulative incidence of PAD, LE revascularization and LE amputation in T2D, 1996-2000 to 2011-2015
Estimate (95% CI)
2011-2015vs 1996-2000
aHR (PAD) 0.55(0.52–0.57)
2011-2015vs 1996-2000
aHR (LE revascularization) 0.80(0.71–0.90)
2011-2015vs 1996-2000
aHR (LE amputation) 0.45(0.40–0.51)
- Peripheral artery disease (PAD) cumulative incidence in T2D, 1996-2000 to 2011-2015
- from 6.2 to 3.4%
- Lower-extremity (LE) revascularization cumulative incidence in T2D, 1996-2000 to 2011-2015
- from 0.8 to 0.6%
- LE amputation cumulative incidence in T2D, 1996-2000 to 2011-2015
- from 1.0 to 0.4%
Observational data: associations, not effects.
Further findings
LE amputation by level
- LE amputation decreased at all levels (hip/thigh, knee/lower leg, ankle/foot/toe)
5-year cumulative incidence in general population
- PAD, stable
- 1.2-1.5%
- LE revascularization, stable
- ∼0.4%
- LE amputation, stable
- ∼0.2%
Relative rates of all outcomes, T2D vs matched individuals · 2011-2015
- Two- to threefold higher in T2D than matched individuals
Original publication
Trends in Peripheral Artery Disease, Lower-Extremity Revascularization, and Lower-Extremity Amputation in Incident Type 2 Diabetes: A Danish Population-Based Cohort Study. Diabetes Care. Published 15 November 2024. doi:10.
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