The influence of diabetes on temporal trends in lower extremity revascularisation and amputation for peripheral artery disease: A population‐based repeated cross‐sectional analysis
Authors' conclusion
Diabetes prevalence rates strongly influenced rates of revascularisation and amputation related to PAD. A decrease in amputations related to PAD over time was attenuated by rising diabetes prevalence rates.
Study context
- Population
- Ontario residents aged ≥40 years, 2002–2019; lower extremity revascularisation and amputation related to peripheral artery disease (PAD)
- Exposure
- 2019 vs 2002
- Outcome
- Annual rates of lower extremity revascularisation (open or endovascular) and amputation (toe, foot or leg) related to PAD; rate ratios relative to 2002, crude, diabetes-adjusted and fully adjusted
Methodological detailsgeneralized estimating equation models
- Generalized estimating equation models
Main finding
As reported in the abstract
Revascularisation rate
Each group vs 2002Estimate (95% CI)
2019
unadjusted RR 1.10(1.07–1.13)
2019
diabetes-adjusted RR 0.98(0.96–1.01)
- 2019
- fully-adjusted RR 0.94 (95% CI 0.91–0.96)
Observational data: associations, not effects.
Further findings
| Outcome | 2019 | 2002 | Estimate | |
|---|---|---|---|---|
| Amputation rate | 45.4 /100,000 person-years | 49.5 /100,000 person-years | unadjusted RR 0.78 (95% CI 0.75–0.81) | |
| Amputation rate | diabetes-adjusted RR 0.62 (95% CI 0.60–0.64) | |||
| Amputation rate | fully-adjusted RR 0.58 (95% CI 0.56–0.60) | |||
| 0.512Ratio (log scale) |
Diabetes prevalence
Diabetes prevalence
- Significantly higher diabetes prevalence in 2019 vs 2002
Original publication
The influence of diabetes on temporal trends in lower extremity revascularisation and amputation for peripheral artery disease: A population‐based repeated cross‐sectional analysis. Diabet Med. Published 10 February 2023. doi:10.
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