Glycaemic status, insulin resistance, and risk of infection-related mortality: a cohort study
Authors' conclusion
Both low and high glycaemic levels and insulin resistance were independently associated with increased infection-related mortality risk, indicating a possible role of abnormal glucose metabolism in increased infection-related mortality.
Study context
- Population
- Korean adults with fasting glucose, HbA1c and insulin measured at health-screening examinations, with and without diabetes, followed for up to 15.8 years313 infectious disease deaths
- Participants
- 666,888 adults
- Exposure
- Glucose, HbA1c and homeostatic model assessment of insulin resistance (HOMA-IR) categories
- Outcome
- Infection-related mortality
- Follow-up
- Median 8.3 years
Methodological detailsKangbuk Samsung Health Study, national death records
- Kangbuk Samsung Health Study
- National death records
Main finding
As reported in the abstract
Infection-related mortality by fasting glucose
Each group vs glucose 5.0-5.5Multivariable-adjusted HR (95% CI)
Glucose <5
2.31(1.47–3.64)
Glucose 5.6-6.9
1.65(1.05–2.60)
Glucose ≥7.0
3.41(1.66–7.00)
- Associations of glucose and HbA1c with infection-related mortality were J-shaped
- P for quadratic trend<.05
Observational data: associations, not effects.
Further findings
| Outcome | Multivariable-adjusted HR (CI) | |
|---|---|---|
| Infection-related mortality by insulin resistance, without diabetesHOMA-IR ≥75th centilevs HOMA-IR <75th centile | 1.55 (1.04–2.32) | |
| 0.512Multivariable-adjusted HR (log scale) |
Original publication
Glycaemic status, insulin resistance, and risk of infection-related mortality: a cohort study. Eur J Endocrinol. Published 9 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →