Results From a Randomized Trial of Intensive Glucose Management Using Continuous Glucose Monitoring (CGM) Versus Usual Care in Hospitalized Adults With Type 2 Diabetes: The TIGHT Study
Primary result · CGM-measured mean glucoseResult — go to the resultRisk-adjusted difference −7 mg/dL 95% CI −19 to 5Authors' conclusion
The study's glucose management approach using CGM did not improve glucose levels compared with standard glucose management in the non-intensive care unit hospital setting. A glucose target of 90-130 mg/dL may not be realistic in the current environment of insulin management in the hospital.
Study context
- Population
- Adults with T2D hospitalized in a non-ICU setting, 6 academic hospitals; mean age 61 ± 12 years, mean HbA1c 8.9 ± 2.3%primary analysis
- Participants
- 110 adults
- Comparison
- Intensive CGM-guided therapy vs standard therapy
- Intensiven = 60
- Standardn = 50reference
- Primary endpoint
- Mean glucose measured with CGM
- Follow-up
- During the study
Methodological detailsmulticentre
- Multicentre
Primary result
CGM-measured mean glucose
Risk-adjusted difference
−7 mg/dL
95% CI −19 to 5
P = 0.25
By group
Intensivevs Standard
risk-adjusted difference −7 mg/dL (95% CI −19 to 5); P = 0.25
As reported in the abstract
Secondary outcomes
| Outcome | Intensive | Standard | Adjusted treatment group difference (95% CI) | |
|---|---|---|---|---|
| Key secondary: CGM readings <54 mg/dL | 0.2% | 0.4% | −0.1% (−0.6 to 0.3) | |
| −1−0.500.5Difference (linear scale) |
| Outcome | Intensive | Standard |
|---|---|---|
| Achieved mean glucose target 90-130 mg/dL | 7% | — not stated in the abstract |
— not stated in the abstract
Safety
- Severe hypoglycemia — Standard
- 1 events
Original publication
Results From a Randomized Trial of Intensive Glucose Management Using CGM Versus Usual Care in Hospitalized Adults With Type 2 Diabetes: The TIGHT Study. Diabetes Care. Published 21 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →