Combined impact of prediabetes and hepatic steatosis on cardiometabolic outcomes in young adults
Authors' conclusion
Prediabetes and hepatic steatosis additively increased the risk of cardiometabolic outcomes in young adults. These findings hold significance for physicians as they provide insights into assessing high-risk individuals among young adults with prediabetes.
Study context
- Population
- Young adults <40 years without DM or previous CVD
- Participants
- 896,585 adults
- Exposure
- Prediabetes and/or hepatic steatosis vs normoglycemia without hepatic steatosis
- Outcome
- Incident DM and composite MACE (MI, stroke or cardiovascular death)
- Follow-up
- Median 11.8 years
Main finding
As reported in the abstract
Each group vs normoglycemiaEstimate (95% CI)P value
Prediabetes
HR (incident DM) 2.81(2.74–2.88)
P-value: <0.001Prediabetes
HR (composite MACE) 1.10(1.03–1.17)
P-value: 0.003- Incident DM cases
- 27,437 (3.1%)
- Major adverse cardiovascular events (MACE) cases
- 6,584 (0.7%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident DM by hepatic steatosis stratificationPrediabetes without hepatic steatosisvs NormoglycemiaAdjusted · reference group not stated in abstract | 3.15 (3.05–3.26) | <0.001 | |
| Incident DM by hepatic steatosis stratificationNormoglycemia with hepatic steatosisvs NormoglycemiaAdjusted · reference group not stated in abstract | 2.89 (2.78–3.01) | <0.001 | |
| Incident DM by hepatic steatosis stratificationPrediabetes with hepatic steatosisvs NormoglycemiaAdjusted · reference group not stated in abstract | 6.60 (6.33–6.87) | <0.001 | |
| Composite MACE by hepatic steatosis stratificationPrediabetes without hepatic steatosisvs NormoglycemiaAdjusted · reference group not stated in abstract | 1.05 (0.97–1.13) | 0.235 | |
| Composite MACE by hepatic steatosis stratificationNormoglycemia with hepatic steatosisvs NormoglycemiaAdjusted · reference group not stated in abstract | 1.39 (1.27–1.51) | <0.001 | |
| Composite MACE by hepatic steatosis stratificationPrediabetes with hepatic steatosisvs NormoglycemiaAdjusted · reference group not stated in abstract | 1.60 (1.44–1.78) | <0.001 | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Combined impact of prediabetes and hepatic steatosis on cardiometabolic outcomes in young adults. Cardiovasc Diabetol. Published 21 November 2024. doi:10.
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