Diabetes and infectious disease mortality in Mexico City
Authors' conclusion
In this study of Mexican adults, diabetes was common, frequently poorly controlled, and associated with much higher risks of death due to infection than observed previously, accounting for approximately one-third of all premature mortality due to infection.
Study context
- Population
- Adults ≥35 years recruited from Mexico City 1998–2004, followed up until January 2021; analysis of those aged 35–74 without other prior chronic diseases130,997 analysed
- Participants
- 159,755 adults
- Exposure
- Previously diagnosed and undiagnosed diabetes vs no diabetes
- Outcome
- Death due to infection
- Follow-up
- Until January 2021, deaths at ages 35-74
Methodological detailsCox regression, adjusted rate ratios
- Cox regression
- Adjusted rate ratios
Main finding
As reported in the abstract
Death from infection
Each group vs no diabetesRelative risk (95% CI)
Previously diagnosed diabetes
4.48(4.05–4.95)
Undiagnosed diabetes
2.69(2.31–3.13)
- Deaths due to infectious causes at ages 35-74 during 2.1 million person-years
- 2030
Observational data: associations, not effects.
Further findings
| Outcome | RR (CI) | |
|---|---|---|
| Death from urinary tract infectionPreviously diagnosed diabetesvs No diabetes | 9.68 (7.07–13.3) | |
| Death from skin, bone and connective tissue infectionsPreviously diagnosed diabetesvs No diabetes | 9.19 (5.92–14.3) | |
| Death from septicemiaPreviously diagnosed diabetesvs No diabetes | 8.37 (5.97–11.7) | |
| 0.050.21520Relative risk (log scale) |
| Outcome | Previously diagnosed diabetes | Undiagnosed diabetes |
|---|---|---|
| Prevalence of diabetes · recruitment | 12.3% | 4.9% |
| Mean HbA1c (SD) | 9.1% (2.5%) | — not stated in the abstract |
— not stated in the abstract
Death from infection by diabetes duration and HbA1c, in previously diagnosed diabetes
- RR per 1 year longer diabetes duration
- 1.03 (1.02-1.05)
- RR per 1.0% higher HbA1c
- 1.12 (1.08-1.15)
- Independently associated
Original publication
Diabetes and infectious disease mortality in Mexico City. BMJ Open Diabetes Res Care. Published 8 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →