Diabetes is one of the main drivers of mortality in Mexico: A latent class analysis of chronic diseases using the Mexico City Prospective Study
Authors' conclusion
Even if we identified higher all-cause mortality across the three clusters, our findings highlighted the disproportionate burden of diabetes, particularly among men, as well as the urgent need for targeted and culturally sensitive interventions.
Study context
- Population
- Participants of the Mexico City Prospective Study (67.2% women); clusters from 17 self-reported chronic conditions30,286 died
- Participants
- 154,369 participants
- Exposure
- Chronic disease clusters vs healthy cluster
- Outcome
- All-cause mortality
- Follow-up
- Median 20 years (IQR: 18.6-21.3)
Methodological detailslatent class analysis
- Latent class analysis
Main finding
As reported in the abstract
Each group vs cluster 0Hazard ratio (95% CI)
Cluster 3
2.60(2.51–2.68)
Cluster 2
1.72(1.67–1.77)
Cluster 1
1.26(1.20–1.31)
Observational data: associations, not effects.
Further findings
Sensitivity analyses by sex and HbA1c target (Cluster 3)
- Participants not achieving the HbA1c target, and men in Cluster 3, had the highest mortality risk
Original publication
Diabetes is one of the main drivers of mortality in Mexico: A latent class analysis of chronic diseases using the Mexico City Prospective Study. Diabetes Obes Metab. Published 25 July 2025. doi:10.
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