Metabolomic Profile of Genetic Liability to Type 2 Diabetes Among 125,000 Mexican Adults: A Mendelian Randomization Study
Authors' conclusion
T2D is associated with widespread changes in the circulating metabolome among adults in Mexico, reflecting diverse biological mechanisms and highlighting the importance of effective T2D management, including control of T2D-associated dyslipidemia, in this population.
Study context
- Population
- Men and women aged ≥35 years recruited from Mexico City, 1998–2004included
- Participants
- 125,587 men
- Comparison
- Genetically predicted liability to T2D and 143 metabolic biomarkers
- Outcome
- Associations of genetically predicted T2D liability with 143 metabolic biomarkers (lipids, lipoproteins, fatty acids, amino acids, ketone bodies, other low-molecular-weight biomarkers)
Methodological detailsgenetic risk score of 1,055 T2D-associated variants, eight pathway-specific T2D genetic risk score (GRSs), targeted plasma NMR metabolomics
- Genetic risk score of 1,055 T2D-associated variants
- Eight pathway-specific T2D GRSs
- Targeted plasma NMR metabolomics
Performance
As reported in the abstract
Metabolomic profile of genetic liability to T2D
T2D GRS explained T2D liability
6.0%
Further findings
Pathway-specific T2D GRSs
- All associated with higher T2D risk but showed differential relationships with circulating metabolic biomarkers
Original publication
Metabolomic Profile of Genetic Liability to Type 2 Diabetes Among 125,000 Mexican Adults: A Mendelian Randomization Study. Diabetes Care. Published 27 March 2026. doi:10.
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