Determining Thyroid Biopsy Appropriateness: A Retrospective Study Integrating Clinical Context and Ultrasound Features
Authors' conclusion
This study underscores the value of integrating US findings with clinical context to guide thyroid biopsy decisions and enhance patient-centered care.
Study context
- Population
- Adults undergoing first thyroid fine-needle aspiration (FNA) biopsy, Jan 2016–Dec 2023, University of Florida, ultrasound (US)481 biopsies
- Participants
- 441 adults
- Outcome
- Appropriateness of thyroid biopsy by a tiered framework incorporating US features and clinical factors
Methodological detailsretrospective, single academic center, 899 patients evaluated
- Retrospective
- Single academic center
- 899 patients evaluated
Main finding
As reported in the abstract
Biopsy appropriateness
Likely appropriate (L-APP) by ACR TI-RADS criteria
388 of 481
80.7%
Reclassified from likely inappropriate to L-APP by clinical factors
34 of 481
7%
Reclassified from L-APP to possibly or extremely inappropriate due to limited life expectancy
50 of 481
10%
Extremely inappropriate (EXT-INAP) biopsies
0.8%
4/481
Observational data: associations, not effects.
Original publication
Determining Thyroid Biopsy Appropriateness: A Retrospective Study Integrating Clinical Context and Ultrasound Features. J Clin Endocrinol Metab. Published 24 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →