Percutaneous Laser Ablation for Thyroid Nodules: Efficacy and Safety in 1492 Patients With Median Follow-up of 10 Years or More
Authors' conclusion
In the largest cohorts reported to date, ultrasound-guided laser ablation of thyroid lesions showed long-term efficacy and safety for treatment of nontoxic and toxic nodules, based on median follow-ups of 10 years or more.
Study context
- Population
- Patients with benign thyroid nodules treated with a single US-guided percutaneous laser ablation, May 2009–July 2024
- Participants
- 1,492 patients
- Exposure
- Nontoxic nodules vs Toxic nodules
- Nontoxic nodulesn = 1,291
- Toxic nodulesn = 201
- Outcome
- Nodule volume reduction (VRR)
- Follow-up
- 1 and 10 years
Main finding
As reported in the abstract
Median VRR
- Nontoxic nodules, median VRR at 1 year
- 70.7%
- Nontoxic nodules, median VRR at 10 years
- 64.1%
- Toxic nodules, median VRR at 1 year
- 63.8%
- Toxic nodules, median VRR at 10 years
- 56.9%
- vs pretreatment at all time points
- P < .001
Observational data: associations, not effects.
Further findings
Median follow-up
Benign nodule regrowth ≥25% · first 3 years
- Cases of regrowth of 25% or greater
- 0
Discontinuation of MMI (toxic nodules) by nodule volume
- Nodules <5 mL
- 100%
- Nodules >25 mL
- 33.3%
- Decreased with increasing nodule volume
Safety
- Major complications
- 0
- Fever
- 15%
- Pain
- 7%
- Hematoma
- 1%
- Overall, minor complications
Original publication
Percutaneous Laser Ablation for Thyroid Nodules: Efficacy and Safety in 1492 Patients With Median Follow-up of 10 Years or More. J Clin Endocrinol Metab. Published 24 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →