Two-year clinical outcomes of microwave ablation for benign thyroid nodules: results from a multicenter study
Authors' conclusion
BTN treatment using the newly developed MWA technique was safe and effective in reducing symptoms and improving cosmetic appearance.
Study context
- Population
- Patients with benign thyroid nodules eligible for microwave ablation (MWA), April 2021–March 2024, Macerata and Peschiera del Garda Hospitals; 23% men, mean age 58.15 ± 13.62 years≥12 months follow-up
- Participants
- 256 patients
- Outcome
- Volume reduction rate (VRR)
- Follow-up
- 1, 3, 6 and 12 months
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Volume reduction rate (VRR) at 1 month
- 47%
- VRR at 3 months
- 60%
- VRR at 6 months
- 71%
- VRR at 12 months
- 71%
- VRR significantly increased over follow-up
- P < .001
Observational data: associations, not effects.
Further findings
Compressive and aesthetic scores · each follow-up vs baseline
- Significantly lower at each follow-up than baseline
- P < 0.001
TSH and FT4 · each follow-up
- Did not change significantly
Nodule volume, subgroup with 24-month follow-up (n=86) · baseline to 24 months
- Nodule volume decreased from 14.54 ± 12.64 to 5.48 ± 4.51
- P < 0.001
VRR, subgroup with 24-month follow-up (n=86) · 1 to 24 months
- VRR increased from 50% at 1 month to 66% at 24 months
- P < 0.001
Safety
| Outcome | Values |
|---|---|
| Post-procedural complications | MWA 7% |
Post-procedural complications
- Mild-moderate, resolved in a few days
Original publication
Two-year clinical outcomes of microwave ablation for benign thyroid nodules: results from a multicenter study. Eur J Endocrinol. Published 14 November 2025. doi:10.
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