Decreased Neutrophils Are Associated With Reduced Risk of Type 2 Diabetes Incidence: Results From the CORDIOPREV Study
Authors' conclusion
These findings suggest that monitoring neutrophils can help prevent the development of T2DM, as a reduction in neutrophil counts could be associated with improved insulin sensitivity. Following a Mediterranean diet might be a potential strategy to reduce the incidence of T2DM by lowering neutrophil levels. Further research is necessary to gain a deeper understanding regarding this mechanism.
Study context
- Population
- Patients without T2D at baseline in the CORDIOPREV study, randomised to a Mediterranean or a low-fat diet107 developed T2D
- Participants
- 462 patients
- Comparison
- Lowest vs middle and highest tertiles of basal neutrophils
- Primary endpoint
- T2D incidence
- Follow-up
- 60 months
Primary result
As reported in the abstract
T2D incidence, overall population
Hazard ratio (95% CI)
Lowest tertilevs Middle tertile
0.499(0.287–0.866)
Lowest tertilevs Highest tertile
0.442(0.255–0.768)
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| T2D incidence, Mediterranean diet subgroupLowest tertilevs Middle tertileAssociation significant only in Mediterranean diet subgroup | 0.423 (0.213–0.842) | |
| T2D incidence, Mediterranean diet subgroupLowest tertilevs Highest tertileAssociation significant only in Mediterranean diet subgroup | 0.371 (0.182–0.762) | |
| 0.20.5125Hazard ratio (log scale) |
Predictive capacity for T2D incidence
- AUC
- 0.711 (95% CI, 0.652-0.769)
- Neutrophils the most important variable in the model
Neutrophil decrease over 60 months vs insulin sensitivity index
- Correlation R (P = .019); particularly with Mediterranean diet
- −0.31
Original publication
Decreased Neutrophils Are Associated With Reduced Risk of Type 2 Diabetes Incidence: Results From the CORDIOPREV Study. J Clin Endocrinol Metab. Published 29 October 2024. doi:10.
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