Reproductive factors predict risks of cardiovascular disease and premature death in postmenopausal women with type 2 diabetes: The Fukuoka Diabetes Registry
Authors' conclusion
Evaluating reproductive factors may help predict the risks of CVD and death in postmenopausal women with type 2 diabetes.
Study context
- Population
- Postmenopausal Japanese women with T2D without pre-existing cardiovascular disease (CVD), Fukuoka Diabetes Registry
- Participants
- 1,592 women
- Exposure
- Reproductive period 30-34, 35-39 and ≥40 years vs ≤29 years
- Outcome
- Composite of:
- CVD incidence
- All-cause death
Methodological detailsregistry-based
- Registry-based
Main finding
As reported in the abstract
Each group vs ≤ 29 yearsMultivariable-adjusted HR (95 % CI)P value
30-34 years
0.80(0.39–1.66)
35-39 years
0.73(0.37–1.43)
≥ 40 years
0.43(0.19–0.99)
P = 0.046for trendObservational data: associations, not effects.
Further findings
- Earlier age at menarche and later age at menopause were associated with decreased risk of the outcome
Original publication
Reproductive factors predict risks of cardiovascular disease and premature death in postmenopausal women with type 2 diabetes: The Fukuoka Diabetes Registry. Diabetes Res Clin Pract. Published 29 October 2024. doi:10.
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