Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus
Authors' conclusion
T2DM was positively linearly related to serum FGF23 concentration and FGF23/α-klotho ratio, and negatively correlated with serum α-klotho concentration. Furthermore, both FGF23 and FGF23/α-klotho ratio were positively correlated with CIMT and atherosclerosis in T2DM patients, while α-klotho was inversely correlated with both CIMT and atherosclerosis, although the associations were not completely significant. Prospective exploration and potential mechanisms underlying these associations remain to be further elucidated.
Study context
- Population
- Chinese patients with and without T2D; serum FGF23 and α-klotho by enzyme-linked immunosorbent assay (ELISA), carotid intima-media thickness (CIMT) by high-resolution color Doppler US
- Participants
- 403 patients
- Exposure
- Tertiles of serum FGF23, α-klotho and FGF23/α-klotho ratio
- T2DMn = 207
- Without T2DMn = 196reference
- Outcome
- Association of serum FGF23, α-klotho and FGF23/α-klotho ratio with T2D and with CIMT and carotid atherosclerosis in T2D patients
Main finding
As reported in the abstract
- Higher tertiles of FGF23 and FGF23/α-klotho ratio positively associated with T2D vs lowest tertile (adjusted); serum α-klotho inversely correlated with T2D
- all P values < 0.01
- Elevated serum FGF23 and FGF23/α-klotho ratio positively associated with CIMT and carotid atherosclerosis in T2D patients
- all P values < 0.01
- Spline analysis: linear dose-response relationship
- all P values < 0.01
- Significant differences in CIMT and carotid atherosclerosis between highest α-klotho group and reference group in T2D patients
- P values = 0.05
Observational data: associations, not effects.
Further findings
Prevalence of atherosclerosis and carotid intima thickening >0.9 mm
- Atherosclerosis
- 41.7%
- Carotid intima thickened >0.9 mm
- 67.2%
Original publication
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