Current Recommended Estrogen Dosing for Pubertal Induction in Turner Syndrome Results in Normal Uterine Growth
Authors' conclusion
Current international guidelines for hormone replacement using 17β-estradiol in individuals with TS appear adequate to allow for normal uterine growth by the end of pubertal induction.
Study context
- Population
- Individuals with Turner syndrome (TS) (age 15–26 years) with POI who reached adult estrogen dosing, Cincinnati Center for Pediatric and Adult Turner Syndrome Care
- Participants
- 29 vs 292
- Exposure
- TS on adult estrogen dosing vs published controls without TS
- TSn = 29
- Controlsn = 292reference
- Outcome
- Uterine length
Methodological detailssingle-centre, comparison with published control sample
- Single-centre
- Comparison with published control sample
Main finding
As reported in the abstract
P = 0.03
Observational data: associations, not effects.
Further findings
Uterine volume · larger in TS
P = 0.02
Original publication
Current Recommended Estrogen Dosing for Pubertal Induction in Turner Syndrome Results in Normal Uterine Growth. J Clin Endocrinol Metab. Published 2 November 2023. doi:10.
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