Gestational diabetes & diabetes in pregnancy
Cord Blood Fetuin-B, Fetal Growth Factors, and Lipids in Gestational Diabetes Mellitus
Authors' conclusion
The study is the first to demonstrate that fetuin-B levels are elevated in fetal life in GDM, and that fetuin-B affects lipid metabolic health during fetal life in humans. The secretion of fetuin-B appears to be related to the secretion of IGF-Ⅰ and IGF-Ⅱ.
Study context
- Population
- Neonates of mothers with gestational diabetes mellitus (GDM) and euglycemic pregnancies, Shanghai Birth Cohort153 pairs
- Comparison
- Neonates of mothers with GDM vs euglycemic pregnancies
- Outcome
- Cord blood fetuin-B concentration
Methodological detailsShanghai Birth Cohort
- Shanghai Birth Cohort
Main finding
As reported in the abstract
Cord blood fetuin-B
P = 0.012
Observational data: associations, not effects.
Further findings
Correlation of cord blood fetuin-B with lipids and fetal growth factors
- Correlation with LDL
- r = 0.239; P < .0001
- Correlation with TC
- r = 0.230; P = .0001
- Correlation with insulin-like growth factor-Ⅰ (IGF-Ⅰ)
- r = 0.137; P = .023
- Correlation with IGF-Ⅱ
- r = 0.148; P = .014
- Similar associations adjusting for maternal and neonatal characteristics
Original publication
Cord Blood Fetuin-B, Fetal Growth Factors, and Lipids in Gestational Diabetes Mellitus. J Clin Endocrinol Metab. Published 29 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →