Contrasting Bone Profiles in Polycystic Ovary Syndrome (PCOS) Are Related to Body Mass Index (BMI): A Systematic Review and Meta-analysis
An erratum to this article was published (J Clin Endocrinol Metab, 16 Sep 2024 ↗)
Authors' conclusion
The findings of this study alert for a low bone mass, low bone formation, and increased bone resorption PCOS with a BMI <27 kg/m2.
Study context
- Population
- Premenopausal women over 18 years old with PCOS; studies 1990–2023 (MEDLINE, Embase)31 studies
- Comparison
- PCOS vs controls
- Outcome
- Bone parameters (bone density, bone turnover markers)
Methodological detailsupdate of a 2019 meta-analysis, Newcastle-Ottawa Scale ≥ 6, stratified by BMI cutoff of 27 kg/m², Data extracted by 2 independent reviewers
- Update of a 2019 meta-analysis
- Newcastle-Ottawa Scale ≥ 6
- Stratified by BMI cutoff of 27 kg/m²
- Data extracted by 2 independent reviewers
Pooled result
As reported in the abstract
Bone parameters stratified by BMI cutoff of 27 kg/m²
- PCOS with BMI <27 kg/m²: lower vertebral and nonvertebral bone density, reduced bone turnover marker (osteocalcin), increased bone resorption marker (C-terminal type I collagen)
- PCOS with BMI ≥27 kg/m²: increased vertebral and nonvertebral BMD, no significant changes in bone formation and resorption markers (except osteocalcin)
- 31 studies; cross-sectional: 1822 PCOS and 1374 controls
Original publication
Contrasting Bone Profiles in PCOS Are Related to BMI: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. Published 13 May 2024. doi:10.
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