High Anti-Müllerian Hormone (AMH) Levels Are Associated With Gestational Hypertension in Patients With PCOS who Underwent IVF/ICSI-ET
Authors' conclusion
High serum AMH level prepregnancy (especially at levels >9.30 ng/mL) indicates a high odds of gestational hypertension in patients with PCOS undergoing fresh embryo transfer.
Study context
- Population
- Patients with PCOS with singleton live births after fresh embryo transfer (IVF/ICSI-ET)
- Participants
- 649 patients
- Exposure
- Higher vs lower serum AMH levels
- Outcome
- Gestational hypertension
Methodological detailspropensity score matching
- Propensity score matching
Main finding
As reported in the abstract
Gestational hypertension per 1 ng/mL increase in AMH
OR per 1 ng/mL AMH (unadjusted)
1.117
95% CI 1.025–1.217P = .012
aOR per 1 ng/mL AMH
1.186
95% CI 1.061–1.327adjusted P = .003
aOR, 75th percentile group (>9.30 ng/mL)
2.635
95% CI 1.132–6.137adjusted P = .025
aOR, 90th percentile group (>12.31 ng/mL)
4.75
95% CI 1.672–13.495adjusted P = .003
Observational data: associations, not effects.
Further findings
AMH predicting gestational hypertension
- AUC
- 0.654 (95% CI 0.532-0.776; P = .011)
- Optimal cutoff
- 11.975 ng/mL
Original publication
High AMH Levels Are Associated With Gestational Hypertension in Patients With PCOS who Underwent IVF/ICSI-ET. J Clin Endocrinol Metab. Published 13 May 2024. doi:10.
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