Topiramate Added to Metformin for Obesity Control in Women With Polycystic Ovary Syndrome
Authors' conclusion
Combining TPM with MTF and a low-calorie diet may be an effective, low-cost, easy-to-use, and safe strategy for weight management in women with PCOS, with mild adverse effects.
Study context
- Population
- Women with polycystic ovary syndrome (PCOS) and BMI ≥30, or ≥27 with hypertension, T2D or dyslipidemia
- Participants
- 30 vs 31
- Comparison
- Topiramate (TPM) added to metformin (MTF) vs placebo added to MTF
- MTF + TPMn = 30
- MTF + Pn = 31reference
- Primary endpoint
- Percentage change in body weight from baseline
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Mean weight change · 6 months
MTF + TPM
−4.5
mean · %
MTF + P
−1.4
mean · %
P = 0.03
Secondary outcomes
Mean, %
| Outcome | MTF + TPM | MTF + P | P value |
|---|---|---|---|
| Mean weight change · 3 monthsGreater weight loss with MTF + TPM | −3.4 | −1.6 | P = 0.03 |
Androgens, lipids and psychosocial scores
- Both groups had improved androgens, lipids, and psychosocial scores
Modified Ferriman-Gallwey score (mFGS) in participants with ≥3% weight loss at 6 months
- mFGS improved from 8.4 to 6.5
- P = 0.026
Safety
Paresthesia · more common with MTF + TPM
P = 0.026
Original publication
Topiramate Added to Metformin for Obesity Control in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. Published 14 September 2024. doi:10.
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