Endogenous Estrogen Exposure and Hypertension Risk; A Population-based Cohort Study With About 2 Decades of Follow-up
Main finding · HTN incidence per 1-SD rise in EEE z-scoreResult — go to the resultUnadjusted hazard ratio .47 95% CI .44-.50Authors' conclusion
This longitudinal study demonstrated the protective effect of a longer EEE duration on HTN risk, even among those with prehypertension status.
Study context
- Population
- Postmenarche normotensive women (3599 premenopausal, 864 menopausal), Tehran Lipid and Glucose Study
- Participants
- 4,463 women
- Exposure
- Endogenous estrogen exposure (EEE) z-score and hypertension (HTN) incidence
- Outcome
- HTN incidence
- Follow-up
- Median 33.2 (25.1, 42.3) years from menarche
Methodological detailsTehran Lipid and Glucose Study, Cox proportional hazards regression (unadjusted and adjusted)
- Tehran Lipid and Glucose Study
- Cox proportional hazards regression (unadjusted and adjusted)
Main finding
HTN incidence per 1-SD rise in EEE z-score · median follow-up 33.2 (25.1, 42.3) years
Unadjusted hazard ratio
.47
95% CI .44-.50
EEE z-score per 1-SD rise
unadjusted HR .47 (95% CI .44-.50)
Per 1-SD rise, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
HTN incidence in participants with prehypertension at baseline
- Hazard of HTN decrease per 1-SD rise in EEE z-score
- 56%
Menopause occurrence
- Menopause occurred in participants
- 31.8%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Endogenous Estrogen Exposure and Hypertension Risk; A Population-based Cohort Study With About 2 Decades of Follow-up. J Clin Endocrinol Metab. Published 9 May 2024. doi:10.
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