Testosterone Therapy Does Not Affect Coagulation in Male Hypogonadism: A Longitudinal Study Based on Thrombin Generation
Authors' conclusion
Hypogonadal men display a procoagulant imbalance detected by increased thrombin generation. Short-term TRT does not worsen global coagulation, suggesting that the treatment can be safely prescribed to men diagnosed with hypogonadism.
Study context
- Population
- Men with hypogonadism (mean age 55 years, SD 13) starting testosterone replacement therapy (TRT) and age-matched healthy controls, 2 tertiary endocrinological ambulatory care centers
- Participants
- 38 / 38 / 38
- Exposure
- Hypogonadal men before (T0) vs 6 months after (T1) starting TRT, and vs healthy controls
- T0n = 38reference
- T1n = 38
- Healthy controls (HCs)n = 38
- Outcome
- Global coagulation by thrombin generation assay (lag time, thrombin peak, time-to-peak, velocity index, ETP)
- Follow-up
- T0 and 6 months after starting TRT (T1)
Methodological detailsobservational, longitudinal, 2 tertiary endocrinological ambulatory care centers, age-matched controls
- Observational
- Longitudinal
- 2 tertiary endocrinological ambulatory care centers
- Age-matched controls
Main finding
As reported in the abstract
TGA parameters, T0 vs T1 · 6 months
- No changes in thrombin generation assay (TGA) parameters between T0 and T1
Observational data: associations, not effects.
Further findings
Hypogonadal men vs HCs: Endogenous thrombin potential (ETP), fibrinogen, antithrombin · T0 and T1
- Significantly higher ETP and fibrinogen and significantly lower antithrombin in hypogonadal men vs HCs at both T0 and T1
Thrombin peak, hypogonadal men vs HCs · T0 and T1
- Significantly higher in hypogonadal men than HCs at T0 but not at T1
Correlation with testosterone levels
- ETP and antithrombin correlated with testosterone levels
Original publication
Testosterone Therapy Does Not Affect Coagulation in Male Hypogonadism: A Longitudinal Study Based on Thrombin Generation. J Clin Endocrinol Metab. Published 8 May 2024. doi:10.
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