Association Between Testosterone Replacement Therapy and Prostatic Disorders in Elderly Hypogonadal Men
Main finding · PCaResult — go to the resultHazard ratio 0.84 95% CI 0.82–0.86Authors' conclusion
TRT use was associated with reduction in PCa hazard and modest increase in BPH hazard. These associations varied by treatment duration, route, and AI coadministration. These findings may inform clinical decision-making regarding TRT use in hypogonadal men and support a more individualized approach to care.
Study context
- Population
- Men aged ≥65 with diagnosed primary or secondary hypogonadism, Medicare enrollment and claims data (Parts A/B/C/D) 2007–2020matched cohort
- Exposure
- Testosterone replacement therapy (TRT) use vs no TRT use
- Outcome
- Prostate outcomes: PCa and BPH
Methodological details1:1 propensity score matching, Cox regression, stratified by age group
- 1:1 propensity score matching
- Cox regression
- Stratified by age group
Main finding
PCa
Hazard ratio
0.84
95% CI 0.82–0.86
TRTvs No TRT
HR 0.84 (95% CI 0.82–0.86)
As reported in the abstract
- Prostate cancer (PCa) risk analysis, after propensity score matching
- 546 964 hypogonadal men
- Reduction in PCa hazard, long-term use
- 15%
- Reduction in PCa hazard, short-term use
- 16%
- Reduction in PCa hazard, parenteral use
- 12%
- Reduction in PCa hazard, topical use
- 13%
Observational data: associations, not effects.
Further findings
PCa, sensitivity analysis excluding elevated PSA and family history of PCa
- Reduction in PCa hazard among TRT users
- 18%
Safety
| Outcome | HR (95% CI) | |
|---|---|---|
| BPH13% increase in hazard · matched cohort | 1.13 (1.11–1.14) | |
| 0.512Hazard ratio (log scale) |
- Benign prostatic hyperplasia (BPH) — BPH risk analysis, after propensity score matching
- 412 782 hypogonadal men
- BPH — Increase in BPH hazard, parenteral TRT
- 19%
- BPH — Increase in BPH hazard, topical TRT
- 12%
- BPH — Increase in BPH hazard, long-term topical use
- 9%
Original publication
Association Between Testosterone Replacement Therapy and Prostatic Disorders in Elderly Hypogonadal Men. J Clin Endocrinol Metab. Published 9 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →