Continuous glucose monitoring as equinox of nocturnal and daytime hypoglycaemia in type 1 diabetes: insights from the randomized controlled HypoDE trial
Authors' conclusion
CGM effectively reduced nocturnal and daytime hypoglycaemia. Without CGM, nocturnal hypoglycaemia contributes to daytime risks, while daytime hypoglycaemia elevates SH risk. Expanding CGM access and addressing nocturnal hypoglycaemia in resource-limited settings are critical.
Study context
- Population
- Adults with T1D, impaired hypoglycaemia awareness, or prior severe hypoglycaemia
- Participants
- 141 adults
- Comparison
- Continuous glucose monitoring (CGM) vs SMBG
Primary result
As reported in the abstract
Baseline: nocturnal exceeded daytime hypoglycaemia (<3.0 mmol/L) exposure by
1.4 percentage points
95% CI 0.6–2.2p < 0.002
Baseline: nocturnal episodes lasted longer
30.7 min
CI 21.5–39.9
With CGM the nocturnal–daytime differences disappeared
0.3 percentage points
<3.0 mmol/L: CI 0.7–1.3
Further findings
Severe hypoglycaemia (SH) risk associated with daytime hypoglycaemia
- IRR per percentage point
- 1.10 (CI 1.01-1.21)
- IRR per minute
- 1.04 (CI 1.01-1.07)
Original publication
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