Diabetes complications

Consistently Low Serum Levels of MG-H1 Are Associated With a Lower Risk of Diabetic Kidney Disease

J Clin Endocrinol MetabPublished Cohort study

Main finding · New or worsening DKDResult — go to the resultHazard ratio 0.48 95% CI 0.29–0.81

Authors' conclusion

Consistently low serum MG-H1 levels are associated with a lower frequency of DKD.

Study context

Population
Patients with poorly controlled diabetes; serum MG-H1 measured twice
Participants
160 patients
Exposure
Consistently low serum MG-H1 vs other
Outcome
New or worsening DKD: 30% decline in eGFR, doubling of serum creatinine, macroalbuminuria, need for renal replacement therapy, or death due to renal disease

Main finding

New or worsening DKD

Hazard ratio

0.48

95% CI 0.29–0.81

P = 0.01

Consistently low MG-H1vs Other
HR 0.48 (95% CI 0.29–0.81); P = 0.01

As reported in the abstract

Observational data: associations, not effects.

Further findings

New or worsening diabetic kidney disease (DKD) in patients without estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m², advanced DKD, or cardiovascular events

Same relationship observed

Original publication

Consistently Low Serum Levels of MG-H1 Are Associated With a Lower Risk of Diabetic Kidney Disease. J Clin Endocrinol Metab. Published 22 February 2025. doi:10.1210/clinem/dgaf098

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