Consistently Low Serum Levels of MG-H1 Are Associated With a Lower Risk of Diabetic Kidney Disease
Main finding · New or worsening DKDResult — go to the resultHazard ratio 0.48 95% CI 0.29–0.81Authors' conclusion
Consistently low serum MG-H1 levels are associated with a lower frequency of DKD.
Study context
- Population
- Patients with poorly controlled diabetes; serum MG-H1 measured twice
- Participants
- 160 patients
- Exposure
- Consistently low serum MG-H1 vs other
- Outcome
- New or worsening DKD: 30% decline in eGFR, doubling of serum creatinine, macroalbuminuria, need for renal replacement therapy, or death due to renal disease
Main finding
New or worsening DKD
Hazard ratio
0.48
95% CI 0.29–0.81
P = 0.01
Consistently low MG-H1vs Other
HR 0.48 (95% CI 0.29–0.81); P = 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
New or worsening diabetic kidney disease (DKD) in patients without estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m², advanced DKD, or cardiovascular events
- Same relationship observed
Original publication
Consistently Low Serum Levels of MG-H1 Are Associated With a Lower Risk of Diabetic Kidney Disease. J Clin Endocrinol Metab. Published 22 February 2025. doi:10. 1210/ clinem/ dgaf098
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