Compromised browning in white adipose tissue of ageing people
Authors' conclusion
PRDM16 and UCP1, despite their key functions in adipose browning, exhibit differential clinical correlations with metabolic features in human WAT in an age-dependent manner. These two genes may participate in the pathogenesis of ageing-related metabolic diseases, but with distinct mechanisms.
Study context
- Population
- Patients with omental adipose tissue collected, 2019–2021; fat depot distribution by CT
- Participants
- 21 / 67 / 34
- Exposure
- Brown adipose markers in white adipose tissue (WAT) across age groups
- Youngn = 21
- Middle-agedn = 67
- Oldern = 34
- Outcome
- Expressions of major brown adipose markers in WAT of different ages, and their associations with metabolic parameters and key adipokines
Main finding
As reported in the abstract
Brown adipose markers in WAT
- UCP1 and PRDM16 mRNA expressions declined with ageing in WAT and were more associated with age than with body mass index (BMI)
- Increased visceral adipose tissue (VAT) amount and VAT/subcutaneous adipose tissue (SAT) ratio decreased in the highest tertile of UCP1 expression; similar fat distribution across PRDM16 mRNA tertiles
- UCP1 mRNA positively correlated with ADIPOQ; correlation strength declined with ageing
- UCP1–LEP association insignificant in young and middle-aged, significant in older people
- Positive correlation between UCP1 and PRDM16
Observational data: associations, not effects.
Original publication
Compromised browning in white adipose tissue of ageing people. Eur J Endocrinol. Published 8 February 2023. doi:10.
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