Propionate Induces Energy Expenditure via Browning in Mesenteric Adipose Tissue
Authors' conclusion
The pronounced response of mesenteric AT to propionate underscores its potential as a therapeutic target for managing abdominal obesity and metabolic disorders.
Study context
- Population
- Patients undergoing open abdominal surgery for cholecystectomy or explorative laparotomy; mesenteric, omental and subcutaneous adipose tissue (AT)
- Participants
- 40 patients
- Comparison
- Propionate 1 mM vs no propionate in mesenteric, omental and subcutaneous AT
- Outcome
- Effects of propionate on human abdominal AT
Methodological detailsex vivo tissue explants and isolated adipocytes
- Ex vivo tissue explants and isolated adipocytes
Main finding
As reported in the abstract
- Propionate upregulated brown fat markers UCP1 and PGC1α in AT and mature adipocytes, particularly of mesenteric origin
- Increased mitochondrial respiration and ATP production, primarily in mesenteric adipocytes
- Improved glucose uptake; reduced lipolysis and inflammation
- Increased thermogenesis, glycolysis and lipogenesis
Original publication
Propionate Induces Energy Expenditure via Browning in Mesenteric Adipose Tissue. J Clin Endocrinol Metab. Published 12 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →