The short ACE2 isoform is upregulated in adipose tissue from women with obesity
Authors' conclusion
Given that short ACE2 expression is induced by interferons, its upregulation in AT under obesity may reflect the interferon-enriched inflammatory environment characteristic of this condition. These findings identify AT, particularly adipocytes, as a relevant site for short ACE2 expression and regulation, expanding current knowledge on short ACE2 isoform biology.
Study context
- Population
- Middle-aged women without obesity (subcutaneous abdominal superficial, abdominal deep, thigh and visceral epiploon adipose tissue (AT)); middle-aged women with previous obesity; older women with and without obesity (subcutaneous abdominal AT)
- Outcome
- Short ACE2 isoform expression in adipose tissue (immunohistochemistry and Western blotting)
Main finding
As reported in the abstract
- Short ACE2 showed comparable expression in subcutaneous and visceral AT, with enrichment in adipocytes
- Full-length ACE2 levels did not significantly differ between stromal vascular fraction (SVF) and adipocytes
- Short ACE2 levels higher in AT from women with obesity vs without obesity
- Short ACE2 expression also elevated in AT from women with previous obesity
Original publication
The short ACE2 isoform is upregulated in adipose tissue from women with obesity. Int J Obes (Lond). Published 29 July 2026. doi:10.
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