Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations
Authors' conclusion
Our findings provide a better understanding of ethnic differences in the age at diagnosis and indicate the potential importance of ethnic differences in the genetic architecture underpinning T2D.
Study context
- Population
- Individuals with T2D from four independent cohorts of European and South Asian Indians
- Participants
- 34,001 individuals4 cohorts
- Comparison
- South Indian vs European
- Outcome
- Genetic variants associated with age at diagnosis of T2D
Methodological detailsfour independent cohorts, multi-ethnic (European and South Asian Indian)
- Four independent cohorts
- Multi-ethnic (European and South Asian Indian)
Pooled result
As reported in the abstract
Genome-wide significant loci for age at T2D diagnosis
- TCF7L2 (chromosome 10q25.3, rs7903146), directionally consistent across ethnic groups, similar frequencies
- P = 2.4 × 10-12, β = −0.436; SE 0.02
- CDKAL1 (chromosome 6p22.3, rs9368219), directionally consistent across ethnic groups, similar frequencies
- P = 2.29 × 10-8; β = −0.053; SE 0.01
- WDR11 (chromosome 10q26.12, rs3011366), specifically in South Indian cohorts
- P = 3.255 × 10-8; β = 1.44; SE 0.25
Further pooled results
Heritability of age at diagnosis
- Heritability estimates much stronger in South Indians than Europeans
Polygenic risk score based on South Indian genome-wide association studies (GWAS)
- Trait variance explained
- ∼2%
Original publication
Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations. Diabetes Care. Published 12 June 2023. doi:10.
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