Combined Detection of Islet Autoantibodies for Clinical Diagnosis of Type 1 Diabetes in the Low-Prevalence Population
Authors' conclusion
Combined autoantibody detection by RBA and ECL assays improved differentiating autoimmune from nonautoimmune diabetes in the low-prevalence population.
Study context
- Population
- Newly diagnosed adult-onset diabetes (≥18 years old)
- Participants
- 633 participants
- Exposure
- Low-prevalence vs high-prevalence population; combined RBA and electrochemiluminescence (ECL) IAb detection
- Low-prevalence populationn = 575
- High-prevalence populationn = 58reference
- Outcome
- Positive islet autoantibodies (IAbs)
Methodological detailsRBA and ECL assays in parallel
- RBA and ECL assays in parallel
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Single IAb positivity among IAb-positive
Single IAb positivity among IAb-positive
- GADA most prevalent single IAb; single-IAb detection in low-prevalence population did not always suggest T1D phenotype
Original publication
Combined Detection of Islet Autoantibodies for Clinical Diagnosis of Type 1 Diabetes in the Low-Prevalence Population. J Clin Endocrinol Metab. Published 8 December 2022. doi:10.
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