Cognitive assessment in patients with primary aldosteronism vs patients with mild autonomous cortisol secretion
Authors' conclusion
Patients with PA demonstrated lower cognition compared with referents and processing speed compared with MACS.
Study context
- Population
- Subjects with hypertension, 2019–2023; PA median age 51.0 years, 57.7% women; Mild autonomous cortisol secretion (MACS) median age 57.0 years, 66.0% women; referents median age 66.1 years, 57.7% women
- Participants
- 52 / 47 / 52
- Exposure
- PA vs referent subjects with hypertension; PA vs MACS
- PAn = 52
- MACSn = 47
- Referentsn = 52reference
- Outcome
- Cognition by National Institute of Health Toolbox Cognition Battery, T-scores corrected for age, sex, race and education
Methodological detailsprospective
- Prospective
Main finding
As reported in the abstract
Cognition (T-scores), adjusted for age, smoking, systolic blood pressure and alcohol use
- PA vs Referents · lower total cognition
- β (total cognition) −5.7; P = 0.023
- PA vs Referents
- β (fluid cognition) −6.8; P = 0.017
- PA vs Referents
- β (attention and executive function) −5.6; P = 0.012
- PA vs Referents
- β (cognitive flexibility and executive function) −8.2; P = 0.006
- PA vs MACS · higher processing speed in PA
- β (processing speed) 9.0; P = 0.003
Observational data: associations, not effects.
Further findings
- No differences in cognition between PA with and without MACS
Original publication
Cognitive assessment in patients with primary aldosteronism vs patients with mild autonomous cortisol secretion. J Clin Endocrinol Metab. Published 14 March 2026. doi:10.
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