Adiposity rebound and height velocity in patients with congenital adrenal hyperplasia
Authors' conclusion
There is a large variation in the timing of adiposity rebound and SITAR-estimated latest peak height velocity in children with CAH. In addition to identifying individuals with CAH who may be at risk of adverse cardiometabolic outcomes these metrics may serve as early surrogate outcomes in future research investigating early-life treatment strategies.
Study context
- Population
- Patients <20 years with CAH due to 21-hydroxylase deficiency in the I-CAH Registry
- Participants
- 573 patients10,261 visits
- Exposure
- Boys vs Girls
- Outcome
- Adiposity rebound
Methodological detailsnon-linear mixed-effects models
- Non-linear mixed-effects models
Main finding
As reported in the abstract
- Adiposity rebound earlier than age 5 years, whole cohort
- 82%
Observational data: associations, not effects.
Further findings
Age at latest peak height velocity
Peak height velocity
Age at latest peak height velocity
- Significant variation in age at latest peak height velocity
Peak height velocity
- Peak height velocity more blunted in boys than girls vs normative values
Glucocorticoid dose and weight, adiposity rebound and bone age
- Girls prescribed higher glucocorticoid doses: heavier weight in adolescence and earlier adiposity rebound
- Bone age increasingly advanced with higher doses in both sexes
Original publication
Adiposity rebound and height velocity in patients with congenital adrenal hyperplasia. Eur J Endocrinol. Published 13 March 2026. doi:10.
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