Sleep Disturbances in Patients With Cushing Syndrome and Mild Autonomous Cortisol Secretion: A Cross-sectional Study
Authors' conclusion
Patients with MACS demonstrate sleep impairment that is similar to patients with CS. Younger women with higher clinical severity of MACS are more likely to have impaired sleep.
Study context
- Population
- Adults with active Cushing syndrome (CS) and mild autonomous cortisol secretion (MACS), and referent subjects; single centre
- Participants
- 154 / 194 / 89
- Exposure
- CS vs MACS vs referent subjects
- CSn = 154
- MACSn = 194
- Referentsn = 89reference
- Outcome
- Sleep quality by Pittsburgh Sleep Quality Index (PSQI)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
PSQI score
CS
12
mean · SD ±4.5
MACS
11
mean · SD 4.6
Referents
5
mean · SD ±3.4
MACS vs Referents: P = <.001 for all · CS vs MACS: P > 0.05 for all
Observational data: associations, not effects.
Further findings
Factors associated with impaired sleep (multivariable analysis)
- MACS: younger age, female sex and higher clinical hypercortisolism severity score associated with impaired sleep
- CS: only younger age associated with poor sleep
Original publication
Sleep Disturbances in Patients With Cushing Syndrome and Mild Autonomous Cortisol Secretion: A Cross-sectional Study. J Clin Endocrinol Metab. Published 6 October 2025. doi:10.
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