Clinical observation and experimental study on the role of choroid‐to‐retina volume ratio in diabetic retinopathy
Authors' conclusion
The study supports the existence of the RBSSR and suggests that CRVR can serve as a potential indicator of RBSSR, highlighting its role in DR pathogenesis.
Study context
- Population
- Diabetic patients; C57BL/6J mice
- Exposure
- Diabetic retinopathy (DR) vs NDR eyes; atropine vs control in mice
- DRn = 125 eyes
- NDRn = 134 eyesreference
- Outcome
- Choroid-to-retina volume ratio (CRVR) as an indicator of the retinal blood supply system reserve
Methodological detailsOptical coherence tomography angiography (OCTA) 12 × 12 mm² fovea-centred scans, C57BL/6J mouse models (atropine; streptozotocin-induced early DR)
- OCTA 12 × 12 mm² fovea-centred scans
- C57BL/6J mouse models (atropine; streptozotocin-induced early DR)
Main finding
As reported in the abstract
CRVR
- Low choroid-to-retina volume ratio (CRVR) is a risk factor for DR (logistic regression and AUC analysis), with all AUC values exceeding 0.70
- DR vs NDR: all p < 0.05
Observational data: associations, not effects.
Further findings
CRVR in mice
- Compared with controls, atropine increased the CRVR in mice
Fundus structure and retinal apoptosis in early DR mouse models
- Atropine-treated eyes had fewer punctate hyperfluorescent lesions, a tighter outer nuclear layer (ONL) arrangement and reduced apoptosis in the ONL and retinal pigment epithelium
Original publication
Clinical observation and experimental study on the role of choroid‐to‐retina volume ratio in diabetic retinopathy. Diabetes Obes Metab. Published 7 May 2025. doi:10.
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