Macrovascular and microvascular complications in US Medicare enrollees with type 2 diabetes with and without atherosclerotic cardiovascular disease
Authors' conclusion
The frequencies of macrovascular and microvascular complications highlight the importance of annual cardiovascular risk assessment in patients with T2D, especially those with established ASCVD.
Study context
- Population
- US Medicare enrollees diagnosed with T2D with and without established ASCVD, 2006–2021
- Participants
- 2,326,726 vs 640,666
- Exposure
- T2D cohort vs T2D + ASCVD sub-cohort
- T2Dn = 2,326,726reference
- T2D + ASCVDn = 640,666
- Outcome
- Incidence of macrovascular and microvascular complications
Methodological detailsMedicare fee-for-service claims data
- Medicare fee-for-service claims data
Main finding
As reported in the abstract
1-year cumulative incidence
- Incidence rate of any macrovascular event, T2D cohort
- 483.34 per 10 000 person-years
- 1-year cumulative incidence of any macrovascular event, overall
- 3.90%
- 1-year cumulative incidence of coronary heart disease, T2D
- 3.24%
- 1-year cumulative incidence of coronary heart disease, T2D + ASCVD
- 8.10%
- 1-year cumulative incidence of peripheral artery disease, T2D
- 1.97%
- 1-year cumulative incidence of peripheral artery disease, T2D + ASCVD
- 7.33%
- Rate of microvascular complications, T2D
- 1569.28 per 10 000 person-years
- Rate of microvascular complications, T2D + ASCVD
- 1859.80 per 10 000 person-years
- 1-year cumulative incidence of any microvascular event, T2D
- 16.88%
- 1-year cumulative incidence of any microvascular event, T2D + ASCVD
- 21.16%
- 1-year cumulative incidence of neuropathy, T2D
- 8.34%
- 1-year cumulative incidence of nephropathy, T2D
- 7.02%
- 1-year cumulative incidence of neuropathy, T2D + ASCVD
- 10.65%
- 1-year cumulative incidence of nephropathy, T2D + ASCVD
- 9.12%
Observational data: associations, not effects.
Original publication
Macrovascular and microvascular complications in US Medicare enrollees with type 2 diabetes with and without atherosclerotic cardiovascular disease. Diabetes Obes Metab. Published 7 May 2025. doi:10.
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