Reduced Aqueous Retinol-Binding Protein 3 Concentration Is Associated With Diabetic Macular Edema and Progression of Diabetic Retinopathy
Authors' conclusion
This study suggests that aqueous RBP3 may be an important protective factor, the first neuroretinal-specific biomarker of DME or DR progression, and a possible therapeutic target.
Study context
- Population
- Patients with T1D or T2D undergoing cataract surgery at Joslin Diabetes Center; 37% no diabetic retinopathy (DR), 40% mild nonproliferative DR (NPDR), 23% moderate NPDR
- Participants
- 153 eyes
- Exposure
- Aqueous RBP3 concentration in relation to diabetic macular edema (DME) history and DR progression
- Outcome
- Association of aqueous RBP3 with DME history and DR progression (≥2-step worsening on ETDRS severity scale)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
P = 0.047
- Elevated RBP3 associated with no DME history (β)
- −0.701 (95% CI −1.151 to 0.250, P = 0.002)
- Elevated baseline RBP3 associated with less subsequent DR progression (OR)
- 0.51 (95% CI 0.28-0.93, P = 0.03)
Observational data: associations, not effects.
Further findings
RBP3 by diabetes type (T1D vs T2D)
- Difference in aqueous RBP3 between T1D and T2D not significant
Multivariable analyses
- RBP3 remained significantly associated with DR progression and DME history
Prediction of DR progression: AUC with RBP3 added to clinical models
- Improvement in AUC
- 5% (P < 0.05)
Original publication
Reduced Aqueous Retinol-Binding Protein 3 Concentration Is Associated With Diabetic Macular Edema and Progression of Diabetic Retinopathy. Diabetes Care. Published 20 November 2024. doi:10.
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