Circulating inflammatory proteins are elevated in type 1 and type 2 diabetes and associated to complications
Authors' conclusion
Both type 1 diabetes and type 2 diabetes are associated with increased circulating inflammatory protein concentrations, but the increase is more pronounced in type 2 diabetes. These results suggest both differences in drivers of inflammation between type 1 diabetes and type 2 diabetes as well as potential similarities in pathways involved in the development of diabetes-associated complications.
Study context
- Population
- People with T1D or T2D and healthy controls; plasma high sensitive C-reactive proteins (hs-CRP) and 92 inflammatory proteins measured
- Participants
- 233 / 387 / 150
- Exposure
- T1D and T2D vs healthy controls
- T1Dn = 233
- T2Dn = 387
- Healthy controlsn = 150reference
- Outcome
- Circulating inflammatory proteins higher vs healthy controls
Methodological detailstargeted proteomics (Olink)
- Targeted proteomics (Olink)
Main finding
As reported in the abstract
Inflammatory proteins higher in T1D vs healthy controls (FDR < 0.05)
41
Inflammatory proteins higher in T2D vs healthy controls (FDR < 0.05)
64
Observational data: associations, not effects.
Further findings
Association of HbA1c with inflammatory proteins in T1D
- Inflammatory proteins positively associated with HbA1c in T1D (incl. CDCP1, FGF-21, HGF, IL-18R1; FDR < 0.05)
- 21
Association of body mass index (BMI) with inflammatory proteins in T2D
- Inflammatory proteins positively associated with BMI in T2D (incl. IL6, IL17C, FGF-23, CSF-1)
- 26
Inflammatory proteins and complications
- Proteins associated with complications, particularly nephropathy, were similar in T1D and T2D
- FlT3L and EN-RAGE associated with development of cardiovascular disease (CVD) in T2D
Original publication
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