Clinical and Pathological Factors Associated with Disease Persistence in Pediatric Patients with Differentiated Thyroid Carcinoma
Authors' conclusion
We identified T4 tumor, lymph node uptake on WBS, and gross ETE as independent factors associated with persistent disease.
Study context
- Population
- Patients aged ≤18 years diagnosed with differentiated thyroid carcinoma (DTC) since January 2000; 74.5% female, median age 15 years (IQR 13–17)
- Participants
- 538 patients
- Outcome
- Persistent disease: biochemical (BIR) or structural (SIR) incomplete response
- Follow-up
- Median 85 months (IQR 42-126 months)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
median follow-up 85 months
- No evidence of disease
- 414/538 (77%)
- Disease persistence
- 124/538 (23.0%)
- BIR
- 68/538 (12.6%)
- SIR
- 56/538 (10.4%)
- Gross extrathyroidal extension (ETE), persistent disease, multivariable OR
- OR 2.81, CI 1.49-5.32, p = 0.0015
- Lymph node uptake at whole-body scan (WBS) after first radioactive iodine treatment (RAIT), persistent disease, multivariable OR
- OR 3.31, CI 1.77-6.19, p = 0.0002
Observational data: associations, not effects.
Further findings
Factors associated with SIR
- T4 tumor, multivariable OR
- OR 4.3, CI 1.38-13.44, p = 0.01
- Lymph node uptake at WBS after first RAIT, multivariable OR
- OR 3.39, CI 1.5-7.67, p = 0.003
- Multivariable analysis
Baseline disease and treatment characteristics · diagnosis
- Lymph node metastases at diagnosis
- 277/530 (52.3%)
- Vascular invasion
- 133/326 (40.8%)
- Gross ETE
- 91/533 (17.1%)
- T4 tumors
- 5%
- RAIT administered
- 493/533 (92.5%)
- More than one RAIT cycle (among treated)
- 138/493 (28%)
Original publication
Clinical and Pathological Factors Associated with Disease Persistence in Pediatric Patients with Differentiated Thyroid Carcinoma. Thyroid. Published 30 July 2025. doi:10.
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