Fluctuations in Thyroid Hormone Levels During Initial Treatment for Differentiated Thyroid Carcinoma are Associated with Changes in Hemostasis: A Prospective Cohort Study
Authors' conclusion
During THST-induced hyperthyroidism, a shift toward a more hypercoagulable and hypofibrinolytic state occurred. However, in vivo activation of hemostasis did not increase.
Study context
- Population
- Patients treated for differentiated thyroid carcinoma (DTC), sampled throughout treatment; 18 female (90%), median age 48 (IQR 35.8–56.5) years
- Participants
- 5 / 20 / 20
- Exposure
- Hemostasis during euthyroidism vs severe hypothyroidism vs thyroid hormone suppression therapy (THST)
- Euthyroidismn = 5
- Severe hypothyroidismn = 20reference
- THSTn = 20
- Outcome
- Changes in hemostatic proteins, CRP, functional hemostasis tests (thrombin generation, clot lysis) and in vivo activation markers (thrombin-antithrombin, PAP complexes, D-dimer)
Methodological detailssecondary study in a larger Dutch prospective cohort, consecutive samples
- Secondary study in a larger Dutch prospective cohort
- Consecutive samples
Main finding
As reported in the abstract
- Increased during THST
- C-reactive protein (CRP), median (IQR) 3.2 (1.3-5.1) vs 1.3 (0.5-3.3) mg/L; P < 0.01
- Increased during THST
- Ex vivo thrombin generation 876.0 (699.0-1052.0) vs 626.0 (477.0-836.3) nM × min; P = 0.02
- Increased during THST
- Ex vivo clot lysis time 76.0 (69.7-95.0) vs 60.6 (55.6-67.4) minutes; P < 0.01
- Reduced during THST
- PAP levels 192.0 (161.0-230.0) vs 266.5 (211.8-312.0) μg/L; P < 0.01
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Fluctuations in Thyroid Hormone Levels During Initial Treatment for Differentiated Thyroid Carcinoma are Associated with Changes in Hemostasis: A Prospective Cohort Study. Thyroid. Published 13 December 2022. doi:10.
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