Evaluating Disease-specific Survival Prediction of Risk Stratification and TNM Systems in Differentiated Thyroid Cancer
Authors' conclusion
In a European population of patients with DTC, of 10 international guidelines using 6 risk of recurrence stratification systems and 1 mortality-based stratification system, our optimized age-adjusted TNM system (8th edition) outperformed all other systems.
Study context
- Population
- Adults with differentiated thyroid cancer (DTC) (79% PTC, 21% FTC) from a Dutch university hospital
- Participants
- 857 adults
- Exposure
- Risk stratification systems of 10 international guidelines vs TNM system (8th edition) for predicting disease-specific survival (DSS)
- Outcome
- Disease-specific survival (DSS) prediction: C-index, Akaike and Bayesian information criteria, proportion of variance explained
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Statistical model performance for predicting DSS
- Dutch guideline had the worst statistical model performance
- 2009 American Thyroid Association (ATA)/2014 British guideline had the best performance among guidelines
- The (adapted) TNM system outperformed all stratification systems
Observational data: associations, not effects.
Further findings
Death because of DTC · median follow-up 9 years
- Died because of DTC
- 67 (7.8%)
Original publication
Evaluating Disease-specific Survival Prediction of Risk Stratification and TNM Systems in Differentiated Thyroid Cancer. J Clin Endocrinol Metab. Published 12 December 2022. doi:10.
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