Patient Redistribution Across Risk Categories in Differentiated Thyroid Cancer Using the 2025 Versus 2015 American Thyroid Association Risk Stratification Systems.
Authors' conclusion
Application of the 2025 ATA RSS resulted in upward reclassification.
Study context
- Population
- Adult differentiated thyroid cancer (DTC) patients (papillary, follicular, oncocytic, high grade, poorly differentiated) who underwent thyroid surgery at a tertiary cancer center, 1999–2025
- Participants
- 843 patients
- Exposure
- 2025 vs 2015 American Thyroid Association (ATA) risk stratification system
- Outcome
- Patient migration across risk categories (2015 vs 2025 ATA RSS)
Methodological detailssingle-centre, tertiary cancer center, Both risk stratification system (RSS) criteria applied to the same cohort using R-based algorithms; analysed descriptively
- Single-centre
- Tertiary cancer center
- Both RSS criteria applied to the same cohort using R-based algorithms; analysed descriptively
Main finding
As reported in the abstract
Patient migration across ATA risk categories (2025 vs 2015 ATA RSS)
- Remained in the same risk category
- 669; 79.4%
- Migrated to a different risk category
- 174 (20.6%)
- 2015 ATA low-risk reclassified to higher-risk categories by 2025 ATA RSS
- 105 (12.6%)
- 2015 low-risk reclassified to 2025 low-intermediate
- 84
- 2015 low-risk reclassified to 2025 intermediate-high
- 21
- Reclassified from 2015 intermediate-risk to 2025 high-risk
- 69 patients (8.2%)
- Change in proportion of low-risk patients under 2025 ATA RSS (decrease)
- 29.7%
- Increase in 2025 ATA intermediate-risk (low-intermediate and intermediate-high) group
- 9.6%
- Increase in 2025 ATA high-risk group
- 8.2%
Observational data: associations, not effects.
Original publication
Patient Redistribution Across Risk Categories in Differentiated Thyroid Cancer Using the 2025 Versus 2015 American Thyroid Association Risk Stratification Systems. Endocr Pract. Published 1 September 2026. doi:10.
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