Risk stratification and long-term monitoring in pediatric thyroid cancer: predictive markers for disease persistence
Authors' conclusion
Early dynamic response is a strong predictor of long-term outcomes and may surpass IRS in prognostic accuracy. sPOTg is a valuable biomarker for both early and late risk assessment. Prospective multicenter validation is warranted.
Study context
- Population
- Patients ≤18 years with differentiated thyroid carcinoma (DTC) treated at a tertiary center83 with complete long-term follow-up
- Participants
- 123 patients
- Exposure
- Early dynamic risk stratification (EDRS) vs IRS for predicting late dynamic response (LDRS)
- Outcome
- Late dynamic response (LDRS)
- Follow-up
- ≥10 years post-treatment
Methodological detailssingle tertiary centre
- Single tertiary centre
Main finding
As reported in the abstract
Association with LDRS · ≥10 years of follow-up
| Group | Value | P |
|---|---|---|
| EDRS | Cramér's V 0.829 | P < 0.001 |
| IRS | Cramér's V 0.33 | P = 0.0029 |
Value
EDRSCramér's V 0.829
IRSCramér's V 0.33
P
EDRSP < 0.001
IRSP = 0.0029
- Concordance between EDRS and LDRS (kappa)
- 0.79
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| sPOTg discrimination for disease persistence | sPOTg AUC at 1-3 years 0.84 (95% CI: 0.70-0.95) · AUC at ≥10 years 0.81 |
Original publication
Risk stratification and long-term monitoring in pediatric thyroid cancer: predictive markers for disease persistence. Eur Thyroid J. Published 13 March 2026. doi:10.
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