Consideration of Early Dynamic Risk Stratification to Guide Discharge from Oncologic Follow-Up in Patients with Differentiated Thyroid Cancer
Authors' conclusion
Low and intermediate recurrence risk DTC patients with excellent response 6 months after total thyroidectomy and radioiodine and in remission 10 years later have an extremely low recurrence risk.
Study context
- Population
- Differentiated thyroid cancers (DTC) patients treated 2008–2012 with excellent response (remission) 6 months after total thyroidectomy and RAI: negative imaging and suppressed thyroglobulin (Tg) <0.2 ng/mL or rh-TSH-stimulated Tg <1 ng/mL (2015 ATA)721 treated for DTC
- Participants
- 492 patients
- Outcome
- Time to recurrence in DTC patients with an excellent response to therapy 6 months after total thyroidectomy and radioiodine therapy
Main finding
As reported in the abstract
Recurrence · mean follow-up 7.0 years; median 7.9 years (IQR 2.1-11.3)
Recurrence
7 patients
1.4%
Recurrences by 2015 ATA initial risk: high / intermediate / low
1 / 3 / 3
All relapses within 10 years after initial management; within first 5 years
4
Observational data: associations, not effects.
Secondary outcomes
Time to suspicion of recurrence (rise in Tg and/or suspicious lymph nodes)
- Detected in first 8 years
- 6 of 7 cases
- Last case detected after initial surgery
- 10 years
Original publication
Consideration of Early Dynamic Risk Stratification to Guide Discharge from Oncologic Follow-Up in Patients with Differentiated Thyroid Cancer. Thyroid. Published 14 October 2024. doi:10.
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